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Contents:

CMB Research Facilities
High-Tech Equipment
Advanced Laboratories and Techniques
CMB Research Areas
CMB Funding Sources



CMB Research facilities

An impressive array of facilities for modern cell and molecular biology research exists among the participating units of the CMB Program. The Macromolecular Structure Facility in the Biochemistry Building has oligonucleotide synthesizers, a peptide synthesizer, peptide sequenators, phosphorimager and chemiluminescent imagers, and a BIAcore surface plasmon resonance instrument. Genomic technology facilities include high-throughput sequencing, oligonucleotide and cDNA microarray production and analysis, and bioinformatics core facilities. The MSU Center for Advanced Microscopy is equipped with both transmission and scanning electron microscopes. An Ortho Cytofluorograph cell sorter is available in the Biochemistry Building, as is the Mass Spectrometry and Proteomics Facility. NMR, ESR, and X-ray diffraction equipment are located in the Chemistry Building. Extensive tissue culture (both plant and animal) and bacterial growth facilities are available, as are animal care rooms and greenhouses for plant growth. In short, essentially the entire gamut of technical facilities needed for modern cell and molecular biology are present at MSU.

High Tech Cell and Molecular Biology Equipment:


494 N-terminal Protein Sequencer

The Molecular Analysis Facility-Located in the Biochemistry building, this facility contains an automated protein sequencer, a peptide synthesizer, and an oligonucleotied synthesizer. ( An additional oligonucleotide synthesizer is available in the DOE Plant Research Lab.)


394 DNA/RNA sequencer


Fluorscence Microscope
The MSU Center for Electron Optics-this facility is equipped with both transmission and scanning electron microscopes.
The Ortho Cytofluorograph cell sorter(under the direction of Dr. Pam Fraker.) The ACAS 470-developed by Dr. Mell Schindler of the CMB program and Dr. Jack Holland of the Biochemistry Department, this device allows cell sorting under anchorage dependent growth conditions. Besides preparative cell sorting, the laser equipped microscope of this instrument is also useful in an number of analytical modes, such as the analysis of cell-cell communication via gap junctions.
Flow Cytometer


A Mass Spectrometer

The NIH-sponsored Regional Mass Spectrometry Facility
(housed by the Biochemistry Department)


Another Mass Spectrometer


NMR, ESR, and X-ray Diffraction equipment are available at the Chemistry Building, nearby to Biochemistry.


Advanced Research Laboratories and Techniques:

Many laboratories of the CMB faculty regularly use recombinant DNA technology and/or hybridoma technology and are fully equipped for these types of research. Extensive tissue culture (both plant and animal) and bacterial growth facilities are located in the Biochemistry Building, Giltner Hall (Microbiology and Physiology), and the Plant Biology Building. Animal care rooms and greenhouses for plant growth are also available.

Research Areas in the CMB Program
Areas of Research Available in the CMB Program at MSU:
(Simply click on your area of interest to view a directory of faculty and their research in that area)

Cancer Research
Developmental Biology
Gene Expression
Immunology and Virology
Molecular Genetics
Molecular Basis of Plant and Animal Diseases
Plant Biology
Protein Structure and Function
Signal Transduction


CMB Funding Sources
The research done by CMB faculty is supported by grants from agencies such as NIH, NSF, USDA, and DOE; foundations such as The American Cancer Society, The American Heart Association,The Michigan Agricultural Experiment Station, and other state and local agencies and foundations.

Additionally, virtually all faculty who participate in the CMB Program have external funding from one or more federal agencies or national charitable foundations.

© 2003 College of Natural Science Cell and Molecular Biology
Michigan State University