Robert W. Wiseman

rwiseman@msu.edu
Phone: (517) 355-6475 ext. 1222
Home Department: Physiology
Radiology

Associate Professor of Physiology and Radiology; Ph.D. Florida State University, 1988.

        The relationship between gene expression and physiologic function is a basic biological problem that relates to all cell types. My laboratory focuses on skeletal muscle and how this cell type and their metabolism adapt to stress such as a change in mechanical loading or pattern of use. We use a broad combination of physiological, biophysical and biochemical methods to understand how metabolism sustains physiologic function and provides the necessarily signals to maintain the stability of the tissue phenotype. Our main research tools are noninvasive techniques as we strive to study the integrated system. Standard biomedical imaging techniques such as magnetic resonance spectroscopy and imaging and fluorescence microscopy offer these advantages. Our approaches primarily use skeletal muscle as the preparation to investigate these issues, however we also study other excitable cells in vivo and in cell and tissue culture.   

Representative Publications

E.G.Shankland, J.C.Livesey, R.W.Wiseman, K.A.Krohn. 2001. Development of an artificial tumor system using A549 cells in exponential growth: Multinuclear NMR studies. Physiol. Res. (accepted).

Muzi, M., S.D. Freeman, R.C. Burrows, R.W. Wiseman, J.M. Link, K.A. Krohn, M.M. Graham and A.M. Spence. 2001. Kinetic characterization of hexokinase isozymes from glioma cells: Implication for FDG imaging of human brain tumors.  Nucl Med Biol. 28(2):107-16.

Meyer, R.A., B.M. Prior, R.I. Siles and R.W. Wiseman. 2001.  Contraction increases the T(2) of muscle in fresh water but not in marine invertebrates. NMR Biomed. 2001 May;14(3):199-203.

A COS link for a more complete description of my research and an update bibliography can be viewed using the following link.  http://myprofile.cos.com/wisemanr52 

Back to CMB Faculty